| | Runs | playerId | seasonId | clubId | matchId | Runs | Player | Team | Season | Grade | Round | Inns | Opponent |
| 1 | 97 | 354928 | 153 | 212 | 3603171 | 97 | Rhiann O'Donnell | Melbourne | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 2 | 1 | Box Hill |
| 2 | 94 | 368249 | 153 | 215 | 3603169 | 94 | Erica Kershaw | Prahran | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 2 | 1 | Dandenong |
| 3 | 86 | 1860790 | 153 | 203 | 3603166 | 86 | Nipuni Hansika | Carlton-Brunswick | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 1 | 1 | Prahran |
| 4 | 85 | 557395 | 153 | 422 | 3603170 | 85 | Sophie Reid | Plenty Valley | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 2 | 1 | Essendon Maribyrnong Park |
| 5 | 80 | 394475 | 153 | 540 | 3603167 | 80 | Jane Neil | Essendon Maribyrnong Park | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 1 | 1 | Melbourne |
| 6 | 79 | 302815 | 153 | 540 | 3603170 | 79 | Natalie Schilov | Essendon Maribyrnong Park | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 2 | 1 | Plenty Valley |
| 7 | 70 | 731086 | 153 | 204 | 3603169 | 70 | Tiana Atkinson | Dandenong | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 2 | 1 | Prahran |
| 8 | 53 | 8145 | 153 | 212 | 3603167 | 53 | Amy J Vine | Melbourne | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 1 | 1 | Essendon Maribyrnong Park |
| 9 | 53 | 636333 | 153 | 217 | 3603172 | 53* | Laura Shaw | Ringwood | 2020/2021 | Kookaburra Women's Premier Firsts One Day | 2 | 1 | Carlton-Brunswick |
Note: Qualification levels for this report are 50 and 100 runs.
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